Last edited by Fauzuru
Tuesday, August 4, 2020 | History

1 edition of Antisense oligonucleotides found in the catalog.

Antisense oligonucleotides

psoralen photoreactivity and enzymatic resistance

by Steven Jay Ugent

  • 233 Want to read
  • 38 Currently reading

Published by s.n.] in [S.l .
Written in English

    Subjects:
  • Psoralens,
  • Antisense nucleic acids,
  • Oligonucleotides

  • Edition Notes

    StatementSteven Jay Ugent
    The Physical Object
    Paginationii, 56 leaves ;
    Number of Pages56
    ID Numbers
    Open LibraryOL26388048M
    OCLC/WorldCa689742072

    This book examines the research and development fields of oligonucleotide (ON) therapeutics, covering topics from the study of antisense and anti-gene effects to drug discovery and development, exploring . Applied antisense oligonucleotide technology. New York: Wiley-Liss, © (OCoLC) Online version: Applied antisense oligonucleotide technology. New York: Wiley-Liss, © (OCoLC) Material Type: Internet resource: Document Type: Book.

      Antisense oligonucleotides are relatively short, single-stranded DNA (Antisense Oligodesoxynucleotides) or single- (Antisense RNA) or double-stranded (short interfering RNA, . Over the years, different types of backbone, nucleobase and/or sugar-modified oligonucleotides have been synthesized because natural DNA/RNA based oligonucleotides pose some limitations, such as .

    Antisense therapeutics: a promise waiting to be fulfilled / Ian Phillips --Antisense inhibition: oligonucleotides, ribozymes and siRNAs / Y. Clare Zhang [and others] --Local application of antisense .   Part 3: Preparation of morpholino. Morpholino antisense oligonucleotides are widely used to modify gene expression by blocking translation of a targeted protein or by modifying pre-mRNA Cited by:


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Antisense oligonucleotides by Steven Jay Ugent Download PDF EPUB FB2

Antisense oligonucleotides (ASOs) have been validated as therapeutic agents and an important tool in molecular biology. Indeed, ASOs are used either Antisense oligonucleotides book vitro or in vivo to generate mRNA selective Author: Sara Karaki, Clément Paris, Palma Rocchi.

Antisense Therapy offers a comprehensive, state-of-the art perspective on the role of antisense therapy in the treatment of human disease, with a special focus on cancer.

Use of antisense oligonucleotides is a growing field of pharmaceutical and biotech companies and research programs for treatment of several diseases. This book. The increasing number of antisense oligonucleotide programs in clinical development is a testament to the progress and understanding of pharmacologic, pharmacokinetic, and toxicologic properties as well as improvement in the delivery of oligonucleotides.

This valuable book Format: Hardcover. Stanley T. Crooke, in Encyclopedia of Cancer (Second Edition), Antisense oligonucleotides are used to hybridize to a specific RNA molecule in vivo and thereby to inhibit its subsequent use; in most. The increasing number of antisense oligonucleotide programs in clinical development is a testament to the progress and understanding of pharmacologic, pharmacokinetic, and toxicologic properties as well as improvement in Antisense oligonucleotides book delivery of oligonucleotides.

This valuable book. Applied Antisense Oligonucleotide Technology provides the basic concepts as well as the practical concerns associated with the use of antisense oligonucleotides to modify gene expression.

Chapters Author: C. Stein. Introduction. There has been a recent revival of interest in the use of antisense oligonucleotides to treat neurodegenerative disorders. Antisense oligonucleotides are synthetic single stranded strings of Cited by:   Efficiency of Antisense Oligonucleotides.

In practice, only a few complementary oligonucleotides can successfully hybridize to a targeted mRNA ().It is assumed that this is largely Cited by: antisense oligonucleotide listen (AN-tee-sents AH-lih-goh-NOO-klee-oh-tide) Small pieces of DNA or RNA that can bind to specific molecules of RNA.

This blocks the ability of the RNA to make a protein. 2. INTRODUCTION: Antisense therapy is a form of treatment for genetic disorders or infections.

When the genetic sequence of a particular gene is known to be causative of a particular. This state-of-the-art reference provides comprehensive coverage of the development of antisense oligonucleotides to inhibit cancer cells as well as those involved in infectious, inflammatory, and Reviews: 1.

antisense eff ects of the ASO. The f ormer cat egory of side effects results fr om the ASO binding to o ff-targ et RN A, producing an und esirable e ffect. The potential for. Antisense oligonucleotides have been investigated as potential drugs for years.

They inhibit target gene or protein expression. The present review summarizes their modifications, modes of action. Extensively revised and updated, Antisense Drug Technology: Principles, Strategies, and Applications, Second Edition reflects the logarithmic progress made in the past four years of oligonucleotide-based therapies, and, in particular, antisense therapeutics and research.

Interpreting lessons learned from the clinical trials of first generation drugs, the book. Applied Antisense Oligonucleotide Technology provides the basic concepts as well as the practical concerns associated with the use of antisense oligonucleotides to modify gene expression.

4/5(1). Book Description. Extensively revised and updated, Antisense Drug Technology: Principles, Strategies, and Applications, Second Edition reflects the logarithmic progress made in the past four years of oligonucleotide-based therapies, and, in particular, antisense therapeutics and research.

Interpreting lessons learned from the clinical trials of first generation drugs, the book. Antisense oligonucleotides (ASOs) are 15–25 nt oligonucleotides designed to tie complementary RNA targets for the degradation.

They are synthesized so that they can be used to block disease 4/5(14). Assessment: Antisense oligonucleotides are used by most investigators as tools for research. What is often lost is the potential of these compounds as drugs to treat diseases.

This book Pages: Leading researchers offer an authoritative survey and analysis of the latest findings on the rapid development of antisense oligonucleotides therapeutic and their application in various in vivo model systems.

The book. Antisense oligonucleotides are relatively short, single-stranded DNA (antisense oligodesoxynucleotides) or single- (antisense RNA) or double-stranded (short interfering RNA, siRNA) RNA molecules. It also critically reviews the problems with antisense therapy, such as the enzymatic destruction of oligonucleotides, the doses required for a therapeutic response, the difficulty in directing.

A new way to block protein function is to prevent the translation of mRNA into Antisense oligonucleotide therapy is one such approach which blocks the protein formation by .With contributions from leading experts, this book is the first to focus solely on addressing the problems and reviewing the strategies currently being used to improve the delivery of antisense nucleic acids.

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